Download Androgens in Health and Disease by Stephen J. Winters MD, Barbara J. Clark PhD (auth.), Carrie PDF

By Stephen J. Winters MD, Barbara J. Clark PhD (auth.), Carrie J. Bagatell MD, William J. Bremner MD, PhD (eds.)

In fresh years, clinical researchers have proven that androgens, either certainly happening and artificial, impact a myriad of physiological capabilities and will even be used therapeutically in a large choice of scientific settings. In Androgens in healthiness and illness, an authoritative panel of researchers and clinicians evaluation our most up-to-date realizing of andrology in either uncomplicated technology and scientific drugs. subject matters diversity from explaining the biology of androgens-from numerous assorted perspectives-to illuminating their function within the improvement and modulation of physiologic platforms. The authors display how testosterone could be a invaluable adjunct to the therapy of a number of illness states, rather these during which catabolism and lack of muscle tissues ensue. different chapters contemplate very important subject matters equivalent to androgen use in athletes, the potential for androgens to enhance actual functionality and caliber of existence in older males, and androgens as strength male contraceptives. Of designated curiosity is a presentation of contemporary advances in figuring out the physiological and medical results of androgen extra and androgen deficiency in ladies.
Authoritative and wide-ranging, Androgens in future health and sickness deals either researchers and training clinicians a finished survey of ways, why, and the place androgens exert their results, in addition to their healing roles in a wide variety of diseases.

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Extra resources for Androgens in Health and Disease

Example text

97. Veldhuis ro, King JC, Urban RI, et al. Operating characteristics ofthe male hypothalarno-pituitarygonadal axis: pulsatile release of testosterone and follicle-stimulating hormone and their temporal coupling with luteinizing hormone. J Clin Endocrinol Metab 1987;65:929-941. 98. Winters SJ, Troen P. Testosterone and estradiol are co-secreted episodically by the human testis. J. Clin Invest 1986;78:870-874. 22 Winters and Clark 99. Vigersky RA, Easley RB, Loriaux DL. Effect of fluoxymesterone on the pituitary-gonadal axis: the role of testosterone-estradiol-binding globulin.

The apparent rate and extent of nuclear import is reduced with ligands that display reduced affinity for the receptor or antagonist acti vity. In the presence of androgens that act as agonists and activate transcription, the nuclear AR appears tightly associated with chromatin and organized within distinct subnuclear compartments. By comparison, when cells are exposed to antagonists, such as the antiandrogens flutamide or bicalutamide, the AR exhibits ligand-dependent migration into the nucleus but does not displayapattern of subnuclear compartmentalization as observed in the presence of androgen.

Altered pulsatile secretion of luteinizing hormone in hypogonadal men with hyperprolactinemia. Clin Endocrinol1984;21:257-263. 55. Bartke A. Effects of growth hormone on male reproductive function. J AndroI2000;21: 181-188. 56. Benton L, Shan LX, Hardy MP. Differentiation of adult Leydig cells. J Steroid Biochem Mol Biol 1995;53:61-68. 57. Baker J, Liu JP, Robertson EJ, et al. Role of insulin-like growth factors in embryonic and postnatal growth. CellI993;75:73-82. 58. Juul A, Andersson AM, Pedersen SA, et al.

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