Download Anti-vegf (Developments in Ophthalmology) by F. Bandello, M. Battaglia Parodi, A.J. Augustin, P. Iacono, PDF

By F. Bandello, M. Battaglia Parodi, A.J. Augustin, P. Iacono, R.O. Schlingemann, U. Schmidt-Erfurth, F.D. Verbraak

The improvement of remedy with anti-angiogenics or vascular endothelial progress issue inhibitors (anti-VEGF) has marked the start of a brand new period in neovascularization and macular edema remedy. Its major targets are the inhibition of progress and improvement of recent vessels besides the aid of vascular permeability. the benefits over traditional laser photocoagulation are obvious as laser therapy regularly leaves scars and factors a retinal sensitivity deterioration. beginning with an overview of therapy rules, this quantity covers all facets of anti-VEGF treatment for ophthalmological issues. specifically, particular chapters are devoted to age-related macular degeneration, degenerative myopia, angioid streaks, inflammatory illnesses, hereditary dystrophies, retinal vein occlusion, diabetic retinopathy, ocular tumors, in addition to anterior section neovascularization. The booklet provides an replace at the software of anti-VEGF in ocular ailments to normal ophthalmologists in addition to retina experts.

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7 Morohoshi K, Goodwin AM, Ohbayashi M, Ono SJ: Autoimmunity in retinal degeneration: autoimmune retinopathy and age-related macular degeneration. J Autoimmun 2009;33:247–254. 34 8 Okemefuna AI, Nan R, Miller A, et al: Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations. J Biol Chem 2010;285:1053–1065. 9 Schmidt-Erfurth U, Pruente C: Management of neovascular age-related macular degeneration. Prog Retin Eye Res 2007;26:437–451. 10 Schmidt-Erfurth U, Richard G, Augustin A, et al: Guidance for the treatment of neovascular agerelated macular degeneration.

17 Aiello LP, Pierce EA, Foley ED, Takagi H, Chen H, Riddle L, et al: Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth-factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci USA 1995;92: 10457–10461. 18 Witmer AN, van Blijswijk BC, Dai J, Hofman P, Partanen TA, Vrensen GFJM, et al: VEGFR-3 in adult angiogenesis. J Pathol 2001;195:490–497. 19 Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, et al: Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele.

15 Petrova TV, Makinen T, Alitalo K: Signaling via vascular endothelial growth factor receptors. Exp Cell Res 1999;253:117–130. 16 Frank RN, Amin RH, Eliott D, et al: Basic fibroblast growth factor and vascular endothelial growth factor are present in epiretinal and choroidal neovascular membranes. Am J Ophthalmol 1996;122: 393–403. Schmidt-Erfurth · Pollreisz · Mitsch · Bolz 17 Kvanta A, Algvere PV, Berglin L, Seregard S: Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor.

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