Download Aquaporins by Baoxue Yang (eds.) PDF

By Baoxue Yang (eds.)

This booklet presents a state of the art record on our present knowing of aquaporins and the longer term path of the sector. Aquaporins (AQPs) are a gaggle of water-channel proteins which are particularly permeable to water and different small molecules, reminiscent of glycerol and urea. so far 13 water-channel proteins (AQP0 – AQP12) were cloned and the mechanisms and physiological features of water shipping throughout organic membranes have lengthy been the topic of curiosity. fresh advances within the molecular biology and body structure of water delivery have yielded new insights into how and why water strikes throughout telephone membranes, and reviews on aquaporin knockout mouse versions recommend that aquaporins are considering the advance of a few illnesses and so they will be worthy objectives of study into selective-inhibitor medicinal drugs. by way of concentrating on the advances revamped the final two decades within the biophysics, genetics, protein constitution, molecular biology, body structure, pathophysiology and pharmacology of aquaporins in mammalian telephone membranes, this e-book presents novel insights into additional mechanisms and the physiological value of water and a few small molecule delivery in mammals with the intention to stimulate additional examine in new directions.

Show description

Read Online or Download Aquaporins PDF

Best health books

67 Ways to Good Sleep

Supplying validated and confirmed how you can get to sleep and remain asleep for the evening, a consultant according to experiences of globally clinical literature and interviews with specialists solutions the key questions and gives innovations to accommodate sleeplessness. Simultaneous.

Skinny-Size It: 101 Recipes That Will Fill You Up and Slim You Down

Picture credits: Tracy Wood

Tired of giving up the nutrients you like simply because you're attempting to drop pounds? cease depriving your self and begin skinny-sizing! Dietician and nutritionist Molly Morgan stocks one hundred and one recipes that provide your high-calorie faves—think pancakes, brownies and lasagna—a thin makeover. the single issues you'll be lacking are these additional kilos.


Traditional breakfast burritos have six hundred energy and 35 grams of fats.

Skinny-Sized burritos have three hundred energy and merely nine grams of fats!

Traditional blueberry cakes have 380 energy and 19 grams of fats

Skinny-Sized blueberry cakes have a hundred thirty energy and a pair of grams of fats!

Traditional lasagna has 870 energy and forty seven grams of fats.

Skinny-Sized lasagna has 260 energy and seven grams of fats!

Strategies for Health Care Finance in Developing Countries

This publication discusses how monetary constraints abate governments in low-income constructing nations attempting to receive speedy advancements in health and wellbeing care. It analyzes how neighborhood groups can do something about those constraints, utilizing case experiences and developments in future health financing, concentrating on group financing in sub-Saharan Africa and its current and destiny roles.

Health improvement and well-being: strategies for action

It really is now commonly said that there's extra to overall healthiness than simply the absence of disorder. This ebook goals to widen the point of view of well-being pros to surround the concept that of health around the lifespan. This ebook is a must-read that addresses the altering roles and wishes of scholars and teachers from quite a lot of future health and social care backgrounds.

Extra info for Aquaporins

Example text

Nico B, Ribatti D (2010) Aquaporins in tumor growth and angiogenesis. Nielsen S, DiGiovanni SR, Christensen EI, Knepper MA, Harris HW (1993) Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney. Nielsen S, Chou CL, Marples D, Christensen EI, Kishore BK, Knepper MA (1995) Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proc Natl Acad Sci U S A 92:1013–1017 173.

4 Docking and Fusion of Vesicles Bearing AQP2 with the Apical tion of microtubules and actin cytoskeletons are Membrane (Exocytosis) essential in its trafficking. The actin cytoskeleton provides a cage anchoring AQP2 in unstimulated Fusion of AQP2-bearing vesicles with the plasma cells, preventing their exocytosis. The binding of membrane is a key terminal step in vasopressin-­ AVP to V2R causes the depolymerization of regulated water transport. The docking and fusF-actin in collecting duct cells, which is critical ing of AQP2-bearing vesicles is mediated by in promoting the trafficking and fusion of AQP2-­ SNARE (Soluble N-ethylmaleimidesensitive facbearing vesicles with the apical membrane [212, tor attachment protein receptors) mechanisms 259].

Preston GM, Carroll TP, Guggino WB, Agre P (1992) Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Preston GM, Jung JS, Guggino WB, Agre P (1993) The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel. Procino G, Barbieri C, Tamma G, De Benedictis L, Pessin JE, Svelto M, Valenti G (2008) AQP2 exocytosis in the renal collecting duct – involvement of SNARE isoforms and the regulatory role of Munc18b. Procino G, Barbieri C, Carmosino M, Rizzo F, Valenti G, Svelto M (2010) Lovastatin-induced cholesterol depletion affects both apical sorting and 31 endocytosis of aquaporin-2 in renal cells.

Download PDF sample

Rated 4.52 of 5 – based on 26 votes